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Anidulafungin for injection
Eraxis™
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FDA Approval: |
February 2006 |
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Indication: |
Candidemia; esophageal candidiasis; intra-abdominal abcess and
peritonitis due to Candida infection |
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Pharmacology: |
Echinocandin antifungal agent |
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Usual Dose: |
Candidemia and Candida infections: 200 mg IV on day 1,
followed by 100 mg daily Esophageal candidiasis: 100 mg IV
on day 1, followed by 50 mg daily |
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Contraindications: |
Hypersensitivity to echinocandins or any ingredients |
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Warnings: |
Do not exceed maximum recommended infusion rate of 1.1 mg/minute
Monitor closely if liver function test abnormalities occur; consider
risk vs. benefit of continuing drug if liver function deteriorates
Safety and efficacy not established in pediatric patients
Lactation: administer only if potential benefit outweighs risk |
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Pregnancy Category: |
C |
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Side Effects: |
Rash, urticaria, flushing, pruritus, dyspnea, hypotension
Diarrhea, nausea, vomiting
Elevated ALT, AST, GGT, alkaline phosphatase
Neutropenia, leukopenia
Hypokalemia
Deep vein thrombosis, phlebitis
Headache, pyrexia |
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Drug Interactions: |
cyclosporine |
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