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Immune Globulin
VIVAGLOBIN®
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FDA Approval: |
January 2006 |
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Indication: |
Treatment of patients with primary immune deficiency (PID) |
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Pharmacology: |
Polyvalent human immunoglobulin |
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Usual Dose: |
Begin treatment one week after receiving a regularly scheduled IGIV
infusion.
Initial weekly dose: calculated by multiplying the previous
IGIV dose by 1.37, then dividing this dose into weekly doses,
administered subcutaneously [based on the patient's previous IGIV
treatment time interval]
Recommended weekly dose: 100 to 200 mg/kg body weight,
subcutaneously. |
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Contraindications: |
Selective immunoglobulin A (IgA) deficiency (serum IgA < 0.05 g/L)
and known antibody against IgA |
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Warnings: |
Do not administer intravenously
If anaphylactic or anaphylactoid reaction are suspected,
discontinue immediately.
Vivaglobin has not been studied in patients younger than 2 years
old.
A positive direct or indirect antiglobulin (Coombs') test may
occur due to the transitory rise of passively transferred antibodies
to erythrocyte antigens. |
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Pregnancy Category: |
C |
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Side Effects: |
Most common: adverse events at the injection site
Anaphylactoid reaction, hypersensitivity reaction, allergic
reaction,
Gastrointestinal disorder, nausea, diarrhea
Headache, fever, pain
Sore throat, increased cough
Skin disorder, rash
Tachycardia |
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Drug Interactions: |
Live attenuated virus vaccines |
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