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Lubiprostone capsules
AMITIZA™
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FDA Approval: |
January 2006 |
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Indication: |
Chronic idiopathic constipation in adults |
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Pharmacology: |
Chloride channel C1C-2 activator |
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Usual Dose: |
24 mcg orally twice a day with food |
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Contraindications: |
History of mechanical GI obstruction
Hypersensitivity to
ingredients |
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Warnings: |
Evaluate patients with signs of GI obstruction before starting drug
Pregnancy must be excluded before starting drug and women must use
effective contraception during treatment
Should not be taken by patients with severe diarrhea
May take with food to reduce nausea
No data exist for use in pediatric patients or patients with
renal or hepatic insufficiency
Nursing mothers should either discontinue breastfeeding or
discontinue the drug |
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Pregnancy Category: |
C |
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Side Effects: |
Nausea, diarrhea, flatulence, vomiting, abdominal pain & distension
Headache, dizziness, hypoesthesia
Edema, fatigue, chest discomfort, infections
Arthralgia, back & extremity pain
Dyspnea, cough, pharyngolaryngeal pain
Depression, anxiety, insomnia |
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Drug Interactions: |
None known |
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