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Maraviroc oral tablets
SELZENTRY® |
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FDA Approval: |
August 2007 |
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Indication: |
HIV-1 (treatment-experied adults with CCR5-tropic HIV-1 detectable strains of
HIV with multiple drug resistance) |
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Pharmacology: |
CCR5 co-receptor antagonist |
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Usual Dose: |
Adults: 150 mg to 600 mg orally twice a day; adjust dose depending on
concomitant use of CYP3A4 inhibitors or inducers |
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Contraindications: |
none known |
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Warnings: |
Monitor: For symptoms of systemic allergic reaction and hepatotoxicity; immune
reconstitution syndrome; evidence of infections Use caution: Patients
with pre-existing liver dysfunction, renal impairment, co-infection with
hepatitis B or C, at risk of cardiovascular events
Safety and efficacy not established in patients < 16 years old
Lactating women should not breast-feed |
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Pregnancy Category: |
B |
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Side Effects: |
Common: Cough
Pyrexia
Upper respiratory tract infections
Rash
Musculoskeletal symptoms
Addominal pain
Dizziness |
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Drug Interactions: |
CYP3A4 inhibitors and inducers Efavirenz
Delavirdine
Nevirapine
Tipranavir/ritonavir |
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Copyright 2006-2007 Cerner Multum, Inc.
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