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Nabilone capsules
CESAMET™
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FDA Approval: |
16 May 2006 |
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Indication: |
Cancer chemotherapy-associated nausea and vomiting when conventional
antiemetics have been ineffective |
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Pharmacology: |
Synthetic cannabinoid |
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Usual Dose: |
1 to 2 mg orally twice a day. Give 1 to 3 hours before
antineoplastics on chemotherapy days. |
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Contraindications: |
Hypersensitivity to cannabinoids
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Warnings: |
Psychiatric side effects may occur for up to 48 to 72 hours after
discontinuation CNS side effects may include dizziness,
drowsiness, euphoria, ataxia, anxiety, disorientation, depression,
hallucinations, and psychosis
Patients should be supervised by a responsible adult while taking
nabilone
May cause tachycardia and orthostatic hypotension
Patients should not drive, operate machinery, or engage in other
activities requiring mental alertness and coordination
Alcohol, sedatives, hypnotics, and psychoactive agents should be
avoided
Caution is recommended in the elderly, hypertension, heart
disease, psychiatric disorders, history of substance abuse,
concomitant use of CNS-active drugs, pregnancy, breastfeeding, and
pediatric patients
Safety has not been established in renal and liver insufficiency
CSA schedule II |
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Pregnancy Category: |
C |
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Side Effects: |
Most common: drowsiness, vertigo, dry mouth, euphoria, ataxia,
headache, difficulty concentrating |
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Drug Interactions: |
amphetamines, cocaine sympathomimetics
anticholinergic agents
tricyclic antidepressants
CNS depressants
disulfiram
fluoxetine
barbiturates
theophylline
opioids
naltrexone
alcohol |
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