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Raltegravir oral tablets
ISENTRESS™ |
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FDA Approval: |
October 2007 |
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Indication: |
HIV-1 in treatment-experienced adults with multiple drug resistant HIV-1 strains |
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Pharmacology: |
HIV integrase strand transfer inhibitor |
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Usual Dose: |
Adults: 400 mg orally twice a day |
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Contraindications: |
none known |
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Warnings: |
Monitor: for immune reconstitution syndrome Caution: with strong UGT 1A1
inducers (e.g., rifampin)
Safety and efficacy not established in patients < 16 years old
Lactating women should not breast-feed |
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Pregnancy Category: |
C |
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Side Effects: |
Common: Nausea
Headache
Diarrhea
Pyrexia
Creatine kinase elevations
Myopathy/rhabdomyolysis |
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Drug Interactions: |
Rifampin Tipranavir/ritonavir |
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