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Rasagiline tablets
AZILECT®
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FDA Approval: |
16 May 2006 |
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Indication: |
Parkinson's disease |
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Pharmacology: |
MAO-B inhibitor |
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Usual Dose: |
Monotherapy: 1 mg orally once a day Adjunct to levodopa: 0.5 mg
orally once a day |
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Contraindications: |
Concomitant meperidine, tramadol, methadone, propoxyphene,
dextromethorphan, St John's wort, mirtazapine, cyclobenzaprine,
sympathomimetics, MAO inhibitors Discontinue at least 14 days
before elective surgery with general anesthesia
Pheochromocytoma |
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Warnings: |
Tyramine-rich foods, SSRIs, SNRIs, TCAs should be avoided Monitor
for symptoms of blood pressure increase and hypertensive crisis
Reduce dose to 0.5 mg/day in patients with mild liver
insufficiency
Avoid in patients with moderate or severe liver insufficiency
Monitor patients for melanoma
May potentiate levodopa-associated dyskinesia
Postural hypotension has occurred, most often during the first 2
months
Advise patients that hallucinations may occur
Caution is recommended during lactation; may inhibit milk
secretion
Safety and efficacy have not been established in pediatric
patients |
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Pregnancy Category: |
C |
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Side Effects: |
Monotherapy, most common: headache, arthralgia, dyspepsia,
depression, fall, flu syndrome Adjunct therapy, most common:
dyskinesia, accidental injury, weight loss, postural hypotension,
vomiting, anorexia, arthralgia, abdominal pain, nausea,
constipation, dry mouth, rash, ecchymosis, somnolence, paresthesia |
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Drug Interactions: |
ciprofloxacin
cyclobenzaprine
dextromethorphan
levodopa
MAO inhibitors
meperidine
methadone
mirtazapine
propoxyphene
St John's wort
sympathomimetics
tramadol
selective serotonin
reuptake inhibitors
selective norepinephrine reuptake inhibitors
tricyclic antidepressants |
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