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Vorinostat capsules
ZOLINZA™ |
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FDA Approval: |
October 6, 2006 |
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Indication: |
Cutaneous manifestations of cutaneous T-cell lymphoma in progressive
or persistent disease |
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Pharmacology: |
Histone deacetylase (HDAC) inhibitor |
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Usual Dose: |
400 mg orally once a day with food |
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Contraindications: |
None |
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Warnings: |
Has been associated with thromboembolism, thrombocytopenia, anemia,
nausea, vomiting, and diarrhea, hyperglycemia, QT prolongation
Blood counts, chemistry (electrolytes, glucose, creatinine) should
be monitored every 2 weeks during the first 2 months, then monthly
ECGs should be performed at baseline and periodically; caution in
patients with congenital long QT syndrome, or on concomitant drugs
that cause QT prolongation
Safety and efficacy not established in pediatric patients
Caution recommended in hepatic and/or renal impairment
Nursing mothers should either discontinue breastfeeding or
discontinue the drug |
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Pregnancy Category: |
D |
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Side Effects: |
Diarrhea, nausea, anorexia, weight loss, vomiting, constipation
Fatigue, chills
Thrombocytopenia, anemia
Dysgeusia, dry mouth |
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Drug Interactions: |
Coumarin anticoagulants Valproic acid and other HDAC inhibitors
QT-prolonging drugs |
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